Mechanisms of Differential Branch Growth Control in the Single Axonal Arbor
نویسنده
چکیده
Regulation of branched axonal arbor shape is crucial for proper neuronal wiring as well as for nervous system plasticity. Isolated neurons are capable of extending axons and establishing complicated branched axonal morphology even without cell-extrinsic cues. This occurs by differentially regulating the growth of each terminal in an arbor. However, the mechanisms governing this cell-autonomous process are not fully understood. Here, I present recent findings regarding the intracellular mechanisms mediating terminal-dependent control of growth and retraction in the single axonal arbor.
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ARTICLE HISTORY Received 7 December 2016 Revised 18 January 2017 Accepted 19 January 2017 ABSTRACT Neurons can extend branches from a single axon to send signals to multiple target cells. Axonal arbor morphology must be changed to establish and alternate neuronal wiring properly. For this purpose, the elongation and retraction rate of each terminal in a single axonal arbor are differentially re...
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تاریخ انتشار 2017